Ozempic prescriptions in Los Angeles surge 162%
Fox Information medical contributor Dr. Marc Siegel mentioned the surge of Ozempic prescriptions, his response to the Pope saying a migrant ‘must be acquired’ and a spike in hepatitis instances within the homeless inhabitants in Los Angeles.
Semaglutide medications — together with Ozempic and Wegovy — have been proven to cut back the chance of kidney failure and the chance of demise amongst folks with kidney illness and sort 2 diabetes.
In a trial led by UNSW Sydney between June 2019 and Might 2021, researchers discovered {that a} small weekly dose of semaglutide lessened the chance of “main kidney occasions” by 24%, in accordance with a press launch.
The examine, funded by Novo Nordisk and revealed in The New England Journal of Medication, included greater than 3,500 contributors with type 2 diabetes and continual kidney illness from 28 nations.
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The contributors acquired 1.0 mg per week of semaglutide, which is lower than what is often prescribed for weight loss or diabetes, the discharge famous.
The median follow-up was 3.4 years.
Semaglutide drugs — together with Ozempic and Wegovy — have been proven to cut back the chance of kidney failure and the chance of demise amongst folks with kidney illness and sort 2 diabetes. (iStock)
“It’s the identical chemical compound, however we used a decrease dose … we did that intentionally as a result of folks with kidney illness are typically extra delicate to the consequences and unintended effects of medicine,” mentioned the examine’s lead writer, professor Vlado Perkovic of UNSW Sydney, within the launch.
“That’s useful by way of with the ability to maybe have the drug extra extensively used than might need in any other case been the case given the present provide limitations.”
The group of individuals taking semaglutide had been additionally 18% much less more likely to expertise a heart attack, stroke and different cardiovascular occasions, the examine discovered.
Why does semaglutide have this impact?
Sufferers with sort 2 diabetes and continual kidney illness are at a big danger for kidney failure, cardiovascular occasions and demise, in accordance with Dr. Brett Osborn, a neurologist and longevity expert in Florida.
“The latest examine revealed within the New England Journal of Medication highlights semaglutide’s potential to mitigate these dangers,” Osborn, who was not concerned within the examine, informed Fox Information Digital.
Dr. Brett Osborn, a neurologist and longevity skilled in Florida, famous that sufferers with sort 2 diabetes and continual kidney illness are at a big danger for kidney failure, cardiovascular occasions and demise. (Dr. Brett Osborn)
Semaglutide works by enhancing glycemic management, Osborn famous — which is essential in mitigating diabetic nephropathy (kidney illness).
“It additionally lowers irritation — notably throughout the blood vessel lining,” he mentioned.
This reduces blood vessel injury and improves blood stream by means of the kidneys.
“General, semaglutide affords substantial renal and cardiovascular safety for sufferers with sort 2 diabetes and continual kidney illness,” Osborn mentioned.
“At a base stage, semaglutide, by means of oblique mechanisms, improves vascular well being. The higher blood stream to your organs — be it your coronary heart, mind or kidneys — the longer you are likely to live.”
Semaglutide works by enhancing glycemic management, one physician famous, which is essential in mitigating diabetic nephropathy (kidney illness). (Getty Photos)
Outdoors the spectrum of diabetes, Osborn mentioned he believes these drugs may have a significant influence on human well being, evaluating them to the appearance of antibiotics on the flip of the century.
Dr. Marc Siegel, scientific professor of medication at NYU Langone Medical Center and a Fox Information medical contributor, additionally mentioned this was a “crucial” examine.
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“This lifesaving result’s probably as a result of metabolic results of the drug, which helps with decreasing irritation, overcoming insulin resistance, and enhancing insulin operate and glucose metabolism on the mobile stage,” Siegel informed Fox Information Digital.
“This examine has broader implications for all sufferers who’ve kidney failure.”
“Improved kidney operate means improved coronary heart operate, and stress on the guts from failed kidneys is a significant explanation for heart attack and death.”
Siegel added, “This examine has broader implications for all sufferers who’ve kidney failure or are in danger for it.”
Novo Nordisk, the Denmark-based firm that makes Ozempic and Wegovy, introduced the constructive main outcomes from the trial on the European Renal Affiliation (ERA) Congress in Sweden final week. (LISELOTTE SABROE/Scanpix Denmark/AFP through Getty Photos)
Novo Nordisk, the Denmark-based firm that makes Ozempic and Wegovy, introduced the constructive main outcomes from the trial on the European Renal Affiliation (ERA) Congress in Sweden final week.
“FLOW is the primary ever renal outcomes trial with a GLP-1 receptor agonist, and demonstrated a statistically important discount in kidney illness development, cardiovascular demise, and all-cause mortality danger with semaglutide 1 mg,” Michael Radin, government medical director for diabetes at Novo Nordisk, mentioned in an announcement despatched to Fox Information Digital.
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“This examine highlights our drive to make a significant distinction within the lives of individuals residing with sort 2 diabetes and CKD and to ship improvements to deal with present unmet medical wants in CKD pending FDA approval.”
Wegovy is an injectable prescription weight reduction drugs that has helped folks with weight problems. (Michael Siluk/UCG/Common Photos Group through Getty Photos)
To leverage semaglutide as a therapy for kidney illness, there’s a want to beat provide shortages and conduct analysis about combining the medication with different therapies, the researchers said within the launch.
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Novo Nordisk can even want to hunt regulatory approval for the drug for use for continual kidney illness sufferers.
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“The problem is to get these outcomes into scientific apply, to get the drug utilized by the individuals who will profit from it, who will dwell longer with out dialysis, with out coronary heart assaults, with out strokes, in the event that they take this drug,” Perkovic mentioned.
